The first King’s Daughters—or filles du roi—arrived in New France in 1663, and 800 more would follow over the next decade. Given their numbers, they were not literally the king’s daughters of course.
They were poor and usually of common birth, but their passage and dowry were indeed paid by King Louis XIV for the purpose of empire building: These women were to marry male colonists and have many children, thus strengthening France’s hold on North America. French Canadians can usually trace their ancestry back to one or more of these women.
For more information about the filles du roi, see my earlier article at http://bit.ly/2wG6ecP.
Whenever a small group of people leave a large population (France) to found a new one (New France), they bring with them a particular set of mutations. Some of these mutations will by chance be more common in the new population and others less so. As a result, some rare genetic disorders disproportionately impact French-Canadians.
One of these is Leber’s hereditary optic neuropathy, which causes vision loss, usually in young men. Recently, geneticists using French Canadian genealogy have reexamined the effects of Leber’s and found a striking pattern of inheritance: It seems to show a long-theorized but never-seen-in-humans pattern called the “mother’s curse.”